Designed Experiments for Industry (2 days)

Day 1

Section 1—Introduction to Factorial Design

• Brief description of factorial design
  • The factorial design planning process
• Basics of factorial design (microwave popcorn)
  • Multiple response optimization

Lunch

Section 2—Enhancements for Full Factorials

• Replicated full factorial
  • Explanation of power
• 2⁸ full factorial
  • Blocking

Section 3a—Fractional Factorials

• Fractional factorials
  • 2^8-2 fractional factorial
  • Setup and aliases
• Minimum-run resolution V (MR5) designs

Section 3b—General Factorials

• Immunofluorescent assay optimization
  
  

Day 2

Section 4—Introduction to Response Surface Design

• Factorial with center points
• Introducing Response Surface Methods “RSM”
• Augmenting to central composite design “CCD”
• “Good” response surface designs
• Sizing for precision

Section 5—Response Surface Methodology

• Instructor-led exercise (fluid bed coating)
  • Building the design
  • Details of analysis
  • Optimization

Lunch

Section 6—Constrained Response Surface

• Constrained design space
  • Optimal design
  • Stent spray coating

Section 7—Quality by Design "QbD"

• Quality by Design
• Illustrative example (tableting process)

Section 8—Introduction to Mixture Design

• What makes a mixture?
• Mixture (Scheffé) polynomials
• Simplex lattice designs (synthetic medium)
• Constrained mixture (antiseptic)

Summary

• Next steps

See the DEI course description for further information.